Clickable Polyprolines from Azido-proline <i>N</i>-Carboxyanhydride

Polyproline is a material of great interest in biomedicine due to its helical scaffold structural importance collagen and mucins ability gel change conformations response temperature. Appending function-modulating chemical groups such desirable diversify potential applications. Here, we describe the synthesis high-molecular-weight homo, block, statistical polymers azide-functionalized proline. The azide served as moieties for highly efficient click-grafting, stabilizers polyproline PPII helix, modulators thermoresponsiveness. Saccharides ethylene glycol were utilized explore small-molecule grafting, glutamate form polyelectrolyte bottlebrush architectures. Secondary structure effects both click modifications, well lower critical solution temperature behavior, characterized. polyazidoprolines products tolerated by live human cells are expected find use diverse biomedical